Vayne Build

Item Build: 

1. Doran’s Blade.
2. Berserker’s Greaves
3. Sheen
4. Zeal
5. Phage
6. Trinity Force
7. Vampiric Sceptar
8. B.F. Sword
9. The Bloodthirster
10. Phantom Dancers
11. Last Whisper
12. Infinity Edge (Get rid of your Doran’s Blade to get room for this item)

When I play as Vayne I switch my items around to whatever counters the enemy. This build is built to counter a balanced team. 
Skill Build:

1. Tumble
2. Silver Bolts
3. Condemn
4. Tumble
5. Tumble
6. Final Hour
7. Tumble 
8. Silver Bolts
9. Tumble (Maxed)
10. Silver Bolts
11. Final Hour
12. Silver Bolts
13. Silver Bolts (Maxed)
14. Condemn
15. Condemn
16. Final Hour (Maxed)
17. Condemn
18. Condemn (Maxed)

Runes:Greater Marks of DesolationGreater Seal of AlacrityGreater Glyph of SealingGreater Quint of Desolation
Masteries:When I play Vayne I use a 21/0/9 build. 
In the Offense Tree I get:3 Deadliness1 Cripple4 Sorcery4 Alacrity3 Sunder3 Brute Force2 Lethality1 Havoc
In the Utility Tree I get:3 Perseverence1 Good Hands4 Awareness1 Greed